Overweight people is prone of getting health problems like
developing arthritis, a medical expert says. What usually triggers a
person to undergo the divisive hip replacement from DePuy Orthopeadics,
a unit of Johnson & Johnson, is the development of Arthritis which
is about 10,100 lawsuits were being filed even after it made a recall
in 2010. Arthritis has numerous type which has over 100 medical
conditions. The Osteoarthritis (OA) is considered as the most
frequently complained type of arthritis and usually have an effect on
ageing patients. There are various forms of arthritis which may have an
effect on people at a very untimely age, the Medical News Today website
reports.
Being overweight or obese is one of the most significant and
potentially a risk factors in the development of osteoarthritis. There
are various researches which revealed a strong connection between body
mass index and osteoarthritis of the hip, knee, foot and hand.
However, the mechanism(s) by which obesity contributes to the onset and progression of osteoarthritis are not fully understood.
The strong linked between body mass index, altered limb alignment,
and osteoarthritis of the knee –and the defensive effects of weight loss
— hold up the classic hypothesis that the effects of obesity on the
joint are due to increased bio-mechanical loading and associated
alterations in gait.
However, obesity is now considered to be a low-grade systemic
inflammatory disease. Current researches advise that metabolic factors
associated with obesity alter systemic levels of pro-inflammatory
cytokines that are also associated with osteoarthritis.
Thus, the final pressure of obesity on osteoarthritis may absorb a
complex interaction of genetic, metabolic, and bio-mechanical factors.
In this respect, mouse models of obesity can provide excellent systems
in which to examine causal relationships among these factors. In recent
years, there have been surprisingly few reports examining the effects
of obesity on osteoarthritis using mouse models.
It is always best to be mindful of becoming fit and healthy which
may help a person prevent a chronic disease such as arthritis, of which
the excruciating pain may lead to surgery such as hip replacement and
about which remains the subject of several hip replacement. For more
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